Gametogenesis re-imagined

The ABCs of Biotech for Christians - Eighth in a series - G is for Gamete

Maybe some readers will recall the junior high science class where they learned about human reproduction — and were embarrassed. Gametes are the reproductive cells…

They are also referred to as sex cells. Female gametes are called ova or egg cells, and male gametes are called sperm. Gametes are haploid cells, and each cell carries only one copy of each chromosome. These reproductive cells are produced through a type of cell division called meiosis. During meiosis, a diploid parent cell, which has two copies of each chromosome, undergoes one round of DNA replication followed by two separate cycles of nuclear division to produce four haploid cells. These cells develop into sperm or ova. The ova mature in the ovaries of females, and the sperm develop in the testes of males. Each sperm cell, or spermatozoon, is small and motile. The spermatozoon has a flagellum, which is a tail-shaped structure that allows the cell to propel and move. In contrast, each egg cell, or ovum, is relatively large and non-motile. During fertilization, a spermatozoon and ovum unite to form a new diploid organism. (ref)

A graphic depiction of the process in which gametes are produced is shown here. The way a human is conceived is a marvel— one now being explored for manufacture in a petri dish: A new biotechnology procedure called in vitro gametogenesis or IVG has been practiced in mice.

IVG could become a novel way to have babies by turning any cell in our bodies into sperm or egg cells (5 Things to know about IVG) “Existing assisted-reproduction technologies such as in vitro fertilisation (IVF) and mitochondrial replacement therapy still require gametes – the sperm and the egg – that come from a man and a woman. But that’s not the case for IVG.”

In IVG, an adult human cell that may come from the skin on ones arm or from inside a cheek could be converted into artificial gametes, and then combined to create an embryo that would be implanted to grow to maturity. This technique would be helpful to those who are infertile or who desire to become parents though in a same-sex relationship, etc.

There is a lot to learn about IVG, and to ponder—before it becomes the new IVF. In this video a woman who was conceived through anonymous sperm donation and IVF, speaks out against it. “I don’t want my children to be targeted for their gametes. This social experiment has taken place around the world… You are right Malta to take a stand!” - Dr. Joanna Rose

The video captured my heart because of the earnest people of Malta who turned out in large numbers to rally against a proposed IVF law that would legalize embryo freezing, gamete donation and non-commercial surrogacy. (ref). Malta is an archipelago in the Mediterranean Sea, believed to be the “Melita” where Paul was shipwrecked en route to Rome. (Acts 28:1)

The vote took place just last week. Did Malta’s Parliament reject or accept the amendments to the Embryo Protection Act? We will address that in the next post, H is for Haploid, as the Gametogenesis topic continues.

Florescence casts a new light

The ABCs of Biotech for Christians - Seventh in a series - F is for Florescence

The reason for this blog series is to take an alphabetic tour through biotech to explore whether God is OK with its techniques and accomplishments. We are trying to understand biotechnology in the light of Scripture.

Can a layperson understand complex scientific topics well enough to be able to consider whether they are agreeable for Christians? I hope that anything written here— if incorrect or far-fetched— will encourage comments which can be entered after login. I don’t want to be a Galileo basher but only a voice of warning as a Berean, believing that a layperson can form good opinions based on Bible truths, if the subject under study is understood.

Attempting this seems like a good quest. If we Christians wait too long to delve into these wells of underground blackness, perhaps what emerges will overwhelm our above ground places of respect for life— our homes, churches, governments.

In this post we will consider florescence.

Aequorea4.jpg
By Sierra Blakely, Attribution, Link
You can read a book about it here, but for us laypeople, suffice to say, jellyfish.

The Aequorea victoria pictured is a bioluminescent hydrozoan jellyfish that is found off the west coast of North America. (wikipedia) It is best known as the source of two proteins involved in bioluminescence, aequorin, a photoprotein, and green fluorescent protein (GFP). Their discoverers, Osamu Shimomura and colleagues, won the 2008 Nobel Prize in Chemistry for their work on GFP.

Since 1994, GFP has been “a scientist’s agent” in the field of biotechnology, needing only oxygen and an energy source to function. It makes possible the investigation or monitoring of DNA, cells and organisms to determine all sorts of information relative to immunology, neurobiology, development and carcinogenesis.

Florescence microscopy permits the inspection of specific proteins inside living cells which is not possible with electron microscopy. There is also fluorescence spectroscopy which is useful to researchers and X-ray florescence.

There are currently clinical trials using florescence to discern aspects of early stage Alzheimers disease in people, the safety of immunotherapy in ovarian cancer patients, and other explorations.

Of course, it is one thing to view cells under a microscope using green florescent protein from a jellyfish to light up and differentiate the view, but it is another to inject that into a human so that noninvasive imaging can be done.

Some ethicists today approve of procedures that restore but do not augment humans. Healing but not eugenics is OK. Others would say we should always err on the side of caution. Even though the combining of jellyfish genes with human cells structures may make healing easier, there is a principle involved. What is in God’s mind regarding this procedure? I want to explore this principle further in future posts. Some say that this principle, that of adding genes from one species or kind to another whether in cells, plants or animals, is what defines the biotechnology industry.

It is possible to integrate jellyfish glow into other species in a “germ” or beginning phase of development, so that the cat or monkey (etc) is florescent. See a glow-in-the-dark cat here.

Scientific research must have limits. God is love yet he, like us, or we, like Him, have limits to our kindness and tolerance.

Angel fish
Public Domain, Link

...and every living creature that moveth, which the waters brought forth abundantly, after their kind, and every winged fowl after his kind ... the living creature after his kind, cattle, and creeping thing, and beast of the earth after his kind ...the beast of the earth after his kind, and cattle after their kind, and every thing that creepeth upon the earth after his kind: and God saw that it was good. -Genesis 1

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A SistersSite eBook

Flesh and Bone and The Protestant Conscience is an e-book on Amazon.com. It is 99¢ and in the Amazon lending library as well. It is also available here in PDF format. The book description follows.

Would you let your conscience be your guide?

Does God care if the skin and bone of the dead are passed along to the living for medical uses? Is organ donation OK with God? Should you sign a Living Will?

Did you know that dead organ donors are often anesthetized before their organs are removed? Do you know the current definition of death? The conscience cannot function without facts.

As we ponder the ethics of in vitro fertilization, stem cell research and man-made chimeras, our thoughts trail off. How then should we live? (Ez 33:10)

How should a Christian think about euthanasia by starvation when doctors and the state attorney general all agree it is time to withhold feeding from a brain injured patient? Some things are family matters, but someday it may be our family.

Here is a small book to help you think about whether you want to sign your driver's license, donate a kidney, cremate your loved one, and many other practical questions that may arise in the course of your healthcare decisions or watch over others.

It offers a special focus on the doctrine of the Resurrection that is related to such decisions. Sunday School classes and Bible Study groups could use this book to facilitate discussion about the issues covered.